MGP Database

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MGP004129

UniProt Annotations

Entry Information
Gene Namekinesin family member 20A
Protein EntryKI20A_HUMAN
UniProt IDO95235
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95235-1; Sequence=Displayed; Name=2; IsoId=O95235-2; Sequence=VSP_056007; Note=No experimental confirmation available.;
FunctionMitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.
PtmPhosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle. {ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692}.
SimilarityBelongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. {ECO:0000255|PROSITE- ProRule:PRU00283}.
SimilarityContains 1 kinesin motor domain. {ECO:0000255|PROSITE- ProRule:PRU00283}.
Subcellular LocationGolgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12939256}.
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