MGP Database

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MGP004133

Ontology/Pathway Information

Entrez Gene ID10125
Gene NameRAS guanyl releasing protein 1 (calcium and DAG-regulated)
Gene Symbol RASGRP1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005789 IEA:UniProtKB-SubCellCendoplasmic reticulum membrane
GO:0000139 IEA:UniProtKB-SubCellCGolgi membrane
GO:0042629 IEA:EnsemblCmast cell granule
GO:0016020 TAS:ProtIncCmembrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005509 TAS:ProtIncFcalcium ion binding
GO:0005085 TAS:ReactomeFguanyl-nucleotide exchange factor activity
GO:0008289 TAS:ProtIncFlipid binding
GO:0032862 IEA:EnsemblPactivation of Rho GTPase activity
GO:0007596 TAS:ReactomePblood coagulation
GO:0030154 IEA:UniProtKB-KWPcell differentiation
GO:0001816 IEA:EnsemblPcytokine production
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0002437 IEA:EnsemblPinflammatory response to antigenic stimulus
GO:0045087 TAS:ReactomePinnate immune response
GO:0043303 IEA:EnsemblPmast cell degranulation
GO:0030168 TAS:ReactomePplatelet activation
GO:0007265 TAS:ProtIncPRas protein signal transduction
GO:0014066 IEA:EnsemblPregulation of phosphatidylinositol 3-kinase signaling
GO:0032252 IEA:EnsemblPsecretory granule localization
GO:0007165 TAS:ProtIncPsignal transduction
GO:0047496 IEA:EnsemblPvesicle transport along microtubule
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118778Activation of RAS in B cells
REACT_75774Adaptive Immune System
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_2202Effects of PIP2 hydrolysis
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184GPCR downstream signaling
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_15523Integrin alphaIIb beta3 signaling
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_23898Rap1 signalling
REACT_14797Signaling by GPCR
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_111102Signal Transduction
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