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MGP004143

UniProt Annotations

Entry Information
Gene Nameplexin C1
Protein EntryPLXC1_HUMAN
UniProt IDO60486
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). {ECO:0000250}.
InteractionQ8JL80:EVM139 (xeno); NbExp=3; IntAct=EBI-2927384, EBI-2927425; O75326:SEMA7A; NbExp=4; IntAct=EBI-2927384, EBI-1753538;
PtmN-glycosylated. {ECO:0000269|PubMed:20727575, ECO:0000269|PubMed:9586637}.
SimilarityBelongs to the plexin family. {ECO:0000305}.
SimilarityContains 1 Sema domain. {ECO:0000255|PROSITE- ProRule:PRU00352}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
SubunitMonomer. Homodimer. Interacts with SEMA7A. {ECO:0000269|PubMed:20727575, ECO:0000269|PubMed:9586637}.
Tissue SpecificityDetected in heart, brain, lung, spleen and placenta. {ECO:0000269|PubMed:9586637}.
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