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MGP004153

UniProt Annotations

Entry Information
Gene Namedehydrogenase/reductase (SDR family) member 9
Protein EntryDHRS9_HUMAN
UniProt IDQ9BPW9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BPW9-1; Sequence=Displayed; Name=2; Synonyms=Retinol dehydrogenase homolog isoform-2; IsoId=Q9BPW9-2; Sequence=VSP_015875; Note=No experimental confirmation available.; Name=3; Synonyms=Retinol dehydrogenase homolog isoform-1; IsoId=Q9BPW9-3; Sequence=VSP_015876; Note=No experimental confirmation available.; Name=4; IsoId=Q9BPW9-4; Sequence=VSP_054357; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=9 uM for NADH {ECO:0000269|PubMed:11294878}; KM=72 uM for NAD {ECO:0000269|PubMed:11294878}; KM=5 uM for allopregnanolone {ECO:0000269|PubMed:11294878}; KM=7.5 uM for 3-alpha-androstanediol {ECO:0000269|PubMed:11294878}; KM=24 uM for androsterone {ECO:0000269|PubMed:11294878}; KM=12 uM for dihydrotestosterone {ECO:0000269|PubMed:11294878};
Function3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. {ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084}. Endoplasmic reticulum membrane {ECO:0000305}. Note=Associated with microsomal membranes.
SubunitHomotetramer. {ECO:0000250}.
Tissue SpecificityHighly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node. {ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084}.
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