MGP Database

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MGP004162

UniProt Annotations

Entry Information
Gene NameNME/NM23 nucleoside diphosphate kinase 6
Protein EntryNDK6_HUMAN
UniProt IDO75414
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75414-1; Sequence=Displayed; Name=2; IsoId=O75414-2; Sequence=VSP_036882; Name=3; IsoId=O75414-3; Sequence=VSP_036883;
Catalytic ActivityATP + nucleoside diphosphate = ADP + nucleoside triphosphate. {ECO:0000255|PROSITE-ProRule:PRU10030}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionMajor role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Sequence CautionSequence=AAC69439.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01808.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12828.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96275.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the NDK family. {ECO:0000305}.
Tissue SpecificityExpressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen.
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