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MGP004163

UniProt Annotations

Entry Information
Gene Namecalcitonin receptor-like
Protein EntryCALRL_HUMAN
UniProt IDQ16602
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. {ECO:0000250, ECO:0000269|PubMed:22102369}.
InteractionP06881:CALCA; NbExp=2; IntAct=EBI-962878, EBI-962928; O60895:RAMP2; NbExp=6; IntAct=EBI-962878, EBI-9009040;
Sequence CautionSequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 2 family. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitHeterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2. {ECO:0000250, ECO:0000269|PubMed:20826335, ECO:0000269|PubMed:22102369}.
Tissue SpecificityPredominantly expressed in the lung and heart.
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