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MGP004169

UniProt Annotations

Entry Information
Gene Namecoenzyme Q7 homolog, ubiquinone (yeast)
Protein EntryCOQ7_HUMAN
UniProt IDQ99807
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99807-1; Sequence=Displayed; Name=2; IsoId=Q99807-2; Sequence=VSP_039068;
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250}; Note=Binds 2 iron ions per subunit. {ECO:0000250};
FunctionInvolved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity). {ECO:0000250}.
PathwayCofactor biosynthesis; ubiquinone biosynthesis.
SimilarityBelongs to the COQ7 family. {ECO:0000305}.
Subcellular LocationMitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. {ECO:0000250}.
SubunitInteracts with ADCK4 and COQ6. {ECO:0000269|PubMed:24270420}.
Tissue SpecificityExpressed dominantly in heart and skeletal muscle.
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