MGP Database

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MGP004175

UniProt Annotations

Entry Information
Gene Nametranslocase of inner mitochondrial membrane 17 homolog B (yeast)
Protein EntryTI17B_HUMAN
UniProt IDO60830
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60830-1; Sequence=Displayed; Name=2; IsoId=O60830-2; Sequence=VSP_047215; Note=No experimental confirmation available.;
FunctionEssential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
SimilarityBelongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
Subcellular LocationMitochondrion inner membrane; Multi-pass membrane protein.
SubunitComponent of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. {ECO:0000269|PubMed:23263864}.
Tissue SpecificityExpression is abundant in heart and skeletal muscle, intermediate in brain, and weak in pancreas, placenta, kidney and liver.
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