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MGP004176

UniProt Annotations

Entry Information
Gene Nameglycine-N-acyltransferase
Protein EntryGLYAT_HUMAN
UniProt IDQ6IB77
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6IB77-1; Sequence=Displayed; Name=2; IsoId=Q6IB77-2; Sequence=VSP_024073, VSP_024074;
Biophysicochemical PropertiesKinetic parameters: KM=57.9 mM for benzoyl-CoA {ECO:0000269|PubMed:7802672}; KM=83.7 mM for salicyl-CoA {ECO:0000269|PubMed:7802672}; KM=124 mM for isovaleryl-CoA {ECO:0000269|PubMed:7802672}; KM=198 mM for octanoyl-CoA {ECO:0000269|PubMed:7802672}; Vmax=17.1 umol/min/mg enzyme with benzoyl-CoA as substrate {ECO:0000269|PubMed:7802672}; Vmax=10.1 umol/min/mg enzyme with salicyl-CoA as substrate {ECO:0000269|PubMed:7802672}; Vmax=7.64 umol/min/mg enzyme with isovaleryl-CoA as substrate {ECO:0000269|PubMed:7802672}; Vmax=3.3 umol/min/mg enzyme with octanoyl-CoA as substrate {ECO:0000269|PubMed:7802672};
Catalytic ActivityAcyl-CoA + glycine = CoA + N-acylglycine.
Catalytic ActivityBenzoyl-CoA + glycine = CoA + hippurate.
FunctionMitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. {ECO:0000269|PubMed:22475485, ECO:0000269|PubMed:7802672}.
Sequence CautionSequence=AAB81453.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the glycine N-acyltransferase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:22475485}.
Tissue SpecificityPredominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. {ECO:0000269|PubMed:22475485}.
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