MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004178

UniProt Annotations

Entry Information
Gene Namesprouty homolog 1, antagonist of FGF signaling (Drosophila)
Protein EntrySPY1_HUMAN
UniProt IDO43609
SpeciesHuman
Comments
Comment typeDescription
DomainThe Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
FunctionMay function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
InductionBy FGF signaling.
InteractionP09022:Hoxa1 (xeno); NbExp=3; IntAct=EBI-3866665, EBI-3957603;
SimilarityBelongs to the sprouty family. {ECO:0000305}.
SimilarityContains 1 SPR (sprouty) domain. {ECO:0000255|PROSITE- ProRule:PRU00572}.
Subcellular LocationCytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
  logo