MGP Database

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MGP004181

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, sub-family C (CFTR/MRP), member 4
Protein EntryMRP4_HUMAN
UniProt IDO15439
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=O15439-1; Sequence=Displayed; Name=2; IsoId=O15439-2; Sequence=VSP_035426; Name=3; IsoId=O15439-3; Sequence=VSP_043283, VSP_043284; Note=No experimental confirmation available.; Name=4; IsoId=O15439-4; Sequence=VSP_057413, VSP_043283, VSP_043284; Note=No experimental confirmation available.;
FunctionMay be an organic anion pump relevant to cellular detoxification.
SimilarityBelongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
SimilarityContains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00441}.
SimilarityContains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitInteracts (via PDZ-binding motif) with SNX27 (via PDZ domain). {ECO:0000269|PubMed:22411990}.
Tissue SpecificityWidely expressed, with particularly high levels in prostate, but is barely detectable in liver.
Web ResourceName=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15439";
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