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MGP004183

UniProt Annotations

Entry Information
Gene Namereceptor (G protein-coupled) activity modifying protein 2
Protein EntryRAMP2_HUMAN
UniProt IDO60895
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60895-1; Sequence=Displayed; Name=2; IsoId=O60895-2; Sequence=VSP_055838;
FunctionTransports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:22102369, ECO:0000269|PubMed:9620797}.
InteractionQ16602:CALCRL; NbExp=6; IntAct=EBI-9009040, EBI-962878;
SimilarityBelongs to the RAMP family. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of CALCRL and RAMP2. {ECO:0000250}.
Tissue SpecificityStrongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed:9620797}.
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