MGP Database

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MGP004209

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, sub-family A (ABC1), member 8
Protein EntryABCA8_HUMAN
UniProt IDO94911
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O94911-1; Sequence=Displayed; Name=2; IsoId=O94911-2; Sequence=VSP_020703; Note=No experimental confirmation available.; Name=3; IsoId=O94911-3; Sequence=VSP_053440; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=30.4 uM for estradiol-beta-glucuronide {ECO:0000269|PubMed:12379217}; KM=0.1 uM for LTC4 {ECO:0000269|PubMed:12379217}; KM=10.3 uM for taurochlorate {ECO:0000269|PubMed:12379217}; KM=5.0 uM for PAH {ECO:0000269|PubMed:12379217}; KM=0.5 uM for estrone sulfate {ECO:0000269|PubMed:12379217}; KM=0.4 uM for ochratoxin A {ECO:0000269|PubMed:12379217};
FunctionATP-dependent lipophilic drug transporter. {ECO:0000269|PubMed:12379217}.
Sequence CautionSequence=BAA74845.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the ABC transporter superfamily. ABCA family. {ECO:0000305}.
SimilarityContains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular LocationCell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityWidely expressed with higher expression in heart, skeletal muscle and liver. {ECO:0000269|PubMed:12379217}.
Web ResourceName=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O94911";
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