MGP Database

MGP004210

Record overview

MGPD ID	MGP004210
Gene ID	10352
Species	Homo sapiens (Human)
Gene Name	tryptophanyl tRNA synthetase 2, mitochondrial
Gene Symbol	WARS2
Synonyms	TrpRS;
Alternate names	tryptophan--tRNA ligase, mitochondrial; (Mt)TrpRS; tryptophan tRNA ligase 2, mitochondrial; tryptophan-tRNA ligase; tryptophanyl-tRNA synthetase, mitochondrial;
Chromosome	1
Map Location	1p12
EC Number	6.1.1.2
Summary	Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for WARS2

Proteins

tryptophan--tRNA ligase, mitochondrial isoform 1 precursor

Refseq ID:	NP_056651
Protein GI:	7710154
UniProt ID:	Q9UGM6
mRNA ID:	NM_015836
Length:	360
RefSeq Status:

`MALHSMRKARERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLL ACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKY GEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTA RYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL`

transit_peptide: 1..18
calculated_mol_wt: 2247
peptide sequence: 
MALHSMRKARERWSFIRA

mat_peptide: 19..220
product: tryptophan--tRNA ligase, mitochondrial isoform 2
calculated_mol_wt: 22584
peptide sequence: 
LHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVS
EHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILSMCVLVF
LT

transit_peptide: 1..18
calculated_mol_wt: 2247
peptide sequence: 
MALHSMRKARERWSFIRA

mat_peptide: 19..360
product: tryptophan--tRNA ligase, mitochondrial isoform 1
calculated_mol_wt: 37918
peptide sequence: 
LHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVS
EHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVK
SLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIK
REIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL

tryptophan--tRNA ligase, mitochondrial isoform 2 precursor

Refseq ID:	NP_957715
Protein GI:	41352700
UniProt ID:	Q9UGM6
mRNA ID:	NM_201263
Length:	220
RefSeq Status:

`MALHSMRKARERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLL ACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKY GEFFPVPESILSMCVLVFLT`

transit_peptide: 1..18
calculated_mol_wt: 2247
peptide sequence: 
MALHSMRKARERWSFIRA

mat_peptide: 19..220
product: tryptophan--tRNA ligase, mitochondrial isoform 2
calculated_mol_wt: 22584
peptide sequence: 
LHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVS
EHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILSMCVLVF
LT