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MGP004211

UniProt Annotations

Entry Information
Gene Namehigh mobility group 20B
Protein EntryHM20B_HUMAN
UniProt IDQ9P0W2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9P0W2-1; Sequence=Displayed; Name=2; IsoId=Q9P0W2-2; Sequence=VSP_037131; Name=3; IsoId=Q9P0W2-3; Sequence=VSP_037132;
FunctionRequired for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
InteractionP51587:BRCA2; NbExp=8; IntAct=EBI-713401, EBI-79792;
Sequence CautionSequence=AAC26860.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC26860.1; Type=Frameshift; Positions=223; Evidence={ECO:0000305}; Sequence=AAH21585.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 HMG box DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00267}.
Subcellular LocationNucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.
SubunitComponent of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein. {ECO:0000269|PubMed:11207365, ECO:0000269|PubMed:12493763}.
Tissue SpecificityUbiquitously expressed in adult tissues. {ECO:0000269|PubMed:10773667, ECO:0000269|PubMed:11997092}.
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