MGP Database

MGP004214

Ontology/Pathway Information

Entrez Gene ID	10371
Gene Name	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Gene Symbol	SEMA3A
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030424	IEA:Ensembl	C	axon
GO:0030425	IEA:Ensembl	C	dendrite
GO:0005576	TAS:Reactome	C	extracellular region
GO:0016020	IEA:InterPro	C	membrane
GO:0045499	TAS:BHF-UCL	F	chemorepellent activity
GO:0038191	ISS:BHF-UCL	F	neuropilin binding
GO:0004872	IEA:InterPro	F	receptor activity
GO:0006915	IEA:Ensembl	P	apoptotic process
GO:0007413	IEA:Ensembl	P	axonal fasciculation
GO:0048846	ISS:BHF-UCL	P	axon extension involved in axon guidance
GO:0007411	TAS:BHF-UCL	P	axon guidance
GO:0060385	ISS:BHF-UCL	P	axonogenesis involved in innervation
GO:0021785	IEA:Ensembl	P	branchiomotor neuron axon guidance
GO:0048813	IEA:Ensembl	P	dendrite morphogenesis
GO:0060666	IEA:Ensembl	P	dichotomous subdivision of terminal units involved in salivary gland branching
GO:0021612	IEA:Ensembl	P	facial nerve structural organization
GO:0021828	IEA:Ensembl	P	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0048843	IEA:Ensembl	P	negative regulation of axon extension involved in axon guidance
GO:0010633	IEA:Ensembl	P	negative regulation of epithelial cell migration
GO:0021675	ISS:BHF-UCL	P	nerve development
GO:1901166	ISS:BHF-UCL	P	neural crest cell migration involved in autonomic nervous system development
GO:1903045	IEA:Ensembl	P	neural crest cell migration involved in sympathetic nervous system development
GO:0001764	ISS:BHF-UCL	P	neuron migration
GO:0021772	IMP:UniProtKB	P	olfactory bulb development
GO:2000020	IEA:Ensembl	P	positive regulation of male gonad development
GO:2001224	IEA:Ensembl	P	positive regulation of neuron migration
GO:0048841	IDA:UniProtKB	P	regulation of axon extension involved in axon guidance
GO:0002027	IEA:Ensembl	P	regulation of heart rate
GO:0071526	TAS:BHF-UCL	P	semaphorin-plexin signaling pathway
GO:1902287	IEA:Ensembl	P	semaphorin-plexin signaling pathway involved in axon guidance
GO:1902285	ISS:BHF-UCL	P	semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:0048880	TAS:BHF-UCL	P	sensory system development
GO:0061549	ISS:BHF-UCL	P	sympathetic ganglion development
GO:0048485	TAS:BHF-UCL	P	sympathetic nervous system development
GO:0097490	ISS:BHF-UCL	P	sympathetic neuron projection extension
GO:0097491	ISS:BHF-UCL	P	sympathetic neuron projection guidance
GO:0021637	IEA:Ensembl	P	trigeminal nerve structural organization

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_18266	Axon guidance
REACT_19199	CRMPs in Sema3A signaling
REACT_111045	Developmental Biology
REACT_19236	Sema3A PAK dependent Axon repulsion
REACT_19279	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
REACT_19271	Semaphorin interactions