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MGP004216

UniProt Annotations

Entry Information
Gene Nameinterferon regulatory factor 9
Protein EntryIRF9_HUMAN
UniProt IDQ00978
SpeciesHuman
Comments
Comment typeDescription
FunctionTranscription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
InductionBy IFN-alpha and IFNB1/IFN-beta.
InteractionP48551:IFNAR2; NbExp=6; IntAct=EBI-626526, EBI-958408; P52630:STAT2; NbExp=6; IntAct=EBI-626526, EBI-1546963;
SimilarityBelongs to the IRF family. {ECO:0000255|PROSITE- ProRule:PRU00840}.
SimilarityContains 1 IRF tryptophan pentad repeat DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00840}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:11846981}. Nucleus {ECO:0000269|PubMed:11846981}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
SubunitInteracts with STAT2 in the cytoplasm. Forms the interferon-stimulated gene factor 3 complex (ISGF3) with the heterodimer STAT1:STAT2; upon stimulation.
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