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MGP004220

UniProt Annotations

Entry Information
Gene Namecholine/ethanolamine phosphotransferase 1
Protein EntryCEPT1_HUMAN
UniProt IDQ9Y6K0
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=37 uM for CDP-choline {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:12216837}; KM=101 uM for CDP-ethanolamine {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:12216837}; Vmax=10.5 nmol/min/mg enzyme with CDP-choline as substrate {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:12216837}; Vmax=4.35 nmol/min/mg enzyme with CDP-ethanolamine as substrate {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:12216837};
Catalytic ActivityCDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine. {ECO:0000269|PubMed:10191259}.
Catalytic ActivityCDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine. {ECO:0000269|PubMed:10191259}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:10191259}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:10191259};
FunctionCatalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:10893425}.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
PathwayPhospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
Sequence CautionSequence=AAF61194.1; Type=Frameshift; Positions=276; Evidence={ECO:0000305};
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:12221122}; Multi-pass membrane protein {ECO:0000269|PubMed:12221122}. Nucleus membrane {ECO:0000269|PubMed:12221122}; Multi-pass membrane protein {ECO:0000269|PubMed:12221122}.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:10191259}.
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