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MGP004225

UniProt Annotations

Entry Information
Gene Namemyosin, light chain 9, regulatory
Protein EntryMYL9_HUMAN
UniProt IDP24844
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P24844-1; Sequence=Displayed; Name=2; IsoId=P24844-2; Sequence=VSP_042834;
FunctionMyosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.
MiscellaneousThis chain binds calcium.
PtmPhosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity). {ECO:0000250}.
SimilarityContains 3 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
SubunitMyosin is a hexamer of 2 heavy chains and 4 light chains.
Tissue SpecificitySmooth muscle tissues and in some, but not all, nonmuscle cells.
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