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MGP004226

Record overview

MGPD IDMGP004226
Gene ID10400
SpeciesHomo sapiens (Human)
Gene Namephosphatidylethanolamine N-methyltransferase
Gene Symbol PEMT
SynonymsPNMT; PEAMT; PEMPT; PEMT2;
Alternate namesphosphatidylethanolamine N-methyltransferase;
Chromosome17
Map Location17p11.2
EC Number2.1.1.17
SummaryPhosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
OrthologsView orthologs and multiple alignments for PEMT

Proteins

phosphatidylethanolamine N-methyltransferase isoform 1
Refseq ID:NP_680477
Protein GI:22538478
UniProt ID:Q9UBM1
mRNA ID:NM_148172
Length:236
RefSeq Status:
MKRSGNPGAEVTNSSVAGPDCCGGLGNIDFRQADFCVMTRLLGYVDPLDPSFVAAVITITFNPLYWNVVARWEHKTRKLSRAFGSPYLACYSLSVTILLL
NFLRSHCFTQAMLSQPRMESLDTPAAYSLGLALLGLGVVLVLSSFFALGFAGTFLGDYFGILKEARVTVFPFNILDNPMYWGSTANYLGWAIMHASPTGL
LLTVLVALTYIVALLYEEPFTAEIYRQKASGSHKRS
 
phosphatidylethanolamine N-methyltransferase isoform 2
Refseq ID:NP_680478
Protein GI:22538480
UniProt ID:Q9UBM1
mRNA ID:NM_148173
Length:199
RefSeq Status:
MTRLLGYVDPLDPSFVAAVITITFNPLYWNVVARWEHKTRKLSRAFGSPYLACYSLSVTILLLNFLRSHCFTQAMLSQPRMESLDTPAAYSLGLALLGLG
VVLVLSSFFALGFAGTFLGDYFGILKEARVTVFPFNILDNPMYWGSTANYLGWAIMHASPTGLLLTVLVALTYIVALLYEEPFTAEIYRQKASGSHKRS
 
phosphatidylethanolamine N-methyltransferase isoform 2
Refseq ID:NP_009100
Protein GI:22538482
UniProt ID:Q9UBM1
mRNA ID:NM_007169
Length:199
RefSeq Status:
Protein sequence is identical to GI:22538480 (mRNA isoform)
 
phosphatidylethanolamine N-methyltransferase isoform 3
Refseq ID:NP_001254481
Protein GI:388890237
UniProt ID:Q9UBM1
mRNA ID:NM_001267552
Length:232
RefSeq Status:
MKRSGNPGAEVTNSSVAGPDCCGGLGNIDFRQADFCVMTRLLGYVDPLDPSFVAAVITITFNPLYWNVVARWEHKTRKLSRAFGSPYLACYSLSVTILLL
NFLRSHCFTQAMLSQPRMESLDTPAAYSLGLALLGLGVVLVLSSFFALGFAGTFLGDYFGILKEARVTVFPFNILDNPMYWGSTANYLGWAIIPAPAGAV
GSEARQPHGPAPDGAGGPHLHSGSPIRRALHR
 
phosphatidylethanolamine N-methyltransferase isoform 4
Refseq ID:NP_001254480
Protein GI:388890235
UniProt ID:Q9UBM1
mRNA ID:NM_001267551
Length:214
RefSeq Status:
MKRSGNPGAEADFCVMTRLLGYVDPLDPSFVAAVITITFNPLYWNVVARWEHKTRKLSRAFGSPYLACYSLSVTILLLNFLRSHCFTQAMLSQPRMESLD
TPAAYSLGLALLGLGVVLVLSSFFALGFAGTFLGDYFGILKEARVTVFPFNILDNPMYWGSTANYLGWAIMHASPTGLLLTVLVALTYIVALLYEEPFTA
EIYRQKASGSHKRS
 
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