MGP Database

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MGP004232

UniProt Annotations

Entry Information
Gene Namespondin 2, extracellular matrix protein
Protein EntrySPON2_HUMAN
UniProt IDQ9BUD6
SpeciesHuman
Comments
Comment typeDescription
FunctionCell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}.
SimilarityContains 1 spondin domain. {ECO:0000255|PROSITE- ProRule:PRU00364}.
SimilarityContains 1 TSP type-1 domain. {ECO:0000255|PROSITE- ProRule:PRU00210}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000250}.
SubunitMonomer. Interacts with integrin. {ECO:0000269|PubMed:19153605}.
Tissue SpecificityExpressed in normal lung tissue but not in lung carcinoma cell lines. {ECO:0000269|PubMed:10512675}.
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