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MGP004233

UniProt Annotations

Entry Information
Gene Namespondin 1, extracellular matrix protein
Protein EntrySPON1_HUMAN
UniProt IDQ9HCB6
SpeciesHuman
Comments
Comment typeDescription
FunctionCell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. {ECO:0000250}.
InteractionP05067-4:APP; NbExp=3; IntAct=EBI-2431846, EBI-302641;
SimilarityContains 1 reelin domain. {ECO:0000255|PROSITE- ProRule:PRU00363}.
SimilarityContains 1 spondin domain. {ECO:0000255|PROSITE- ProRule:PRU00364}.
SimilarityContains 6 TSP type-1 domains. {ECO:0000255|PROSITE- ProRule:PRU00210}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000250}.
SubunitBinds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP. {ECO:0000250}.
Tissue SpecificityHighest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen. {ECO:0000269|PubMed:11368520, ECO:0000269|PubMed:9872452}.
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