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MGP004251

UniProt Annotations

Entry Information
Gene Namefollistatin
Protein EntryFST_HUMAN
UniProt IDP19883
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=FS315, FS-315; IsoId=P19883-1; Sequence=Displayed; Name=2; Synonyms=FS288, FS-288; IsoId=P19883-2; Sequence=VSP_001565;
FunctionBinds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
InteractionP03950:ANG; NbExp=3; IntAct=EBI-1571188, EBI-525291; Q14689:DIP2A; NbExp=2; IntAct=EBI-1571188, EBI-2564275;
SimilarityContains 1 TB (TGF-beta binding) domain. {ECO:0000305}.
SimilarityContains 3 follistatin-like domains. {ECO:0000305}.
SimilarityContains 3 Kazal-like domains. {ECO:0000255|PROSITE- ProRule:PRU00798}.
Subcellular LocationSecreted.
SubunitMonomer. {ECO:0000305}.
Tissue SpecificityIsoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. {ECO:0000269|PubMed:15472207}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FSTID44477ch5q11.html";
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