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MGP004257

Record overview

MGPD IDMGP004257
Gene ID10477
SpeciesHomo sapiens (Human)
Gene Nameubiquitin-conjugating enzyme E2E 3
Gene Symbol UBE2E3
SynonymsUBCH9; UbcM2;
Alternate namesubiquitin-conjugating enzyme E2 E3; ubiquitin carrier protein E3; ubiquitin-conjugating enzyme E2-23 kDa; ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5); ubiquitin-protein ligase E3;
Chromosome2
Map Location2q32.1
EC Number6.3.2.19
SummaryThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
OrthologsView orthologs and multiple alignments for UBE2E3

Proteins

ubiquitin-conjugating enzyme E2 E3
Refseq ID:NP_872619
Protein GI:33359694
UniProt ID:Q969T4
mRNA ID:NM_182678
Length:207
RefSeq Status:
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGP
PGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQ
WTKRYAT
 
ubiquitin-conjugating enzyme E2 E3
Refseq ID:NP_001265483
Protein GI:514052664
UniProt ID:Q969T4
mRNA ID:NM_001278554
Length:207
RefSeq Status:
Protein sequence is identical to GI:33359694 (mRNA isoform)
 
ubiquitin-conjugating enzyme E2 E3
Refseq ID:NP_001265484
Protein GI:514052667
UniProt ID:Q969T4
mRNA ID:NM_001278555
Length:207
RefSeq Status:
Protein sequence is identical to GI:33359694 (mRNA isoform)
 
ubiquitin-conjugating enzyme E2 E3
Refseq ID:NP_006348
Protein GI:5454146
UniProt ID:Q969T4
mRNA ID:NM_006357
Length:207
RefSeq Status:
Protein sequence is identical to GI:33359694 (mRNA isoform)
 
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