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MGP004264

UniProt Annotations

Entry Information
Gene Nameleucine rich repeat containing 41
Protein EntryLRC41_HUMAN
UniProt IDQ15345
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q15345-2; Sequence=Displayed; Name=3; IsoId=Q15345-3; Sequence=VSP_009234, VSP_009235; Note=No experimental confirmation available. Ref.7 (BAC86308) sequence differs from that shown due to frameshifts in positions 12, 15 and 38, to erroneous initiation (Translation N-terminally extended) and to miscellaneous discrepancy (The N-terminus differs for unknown reasons). {ECO:0000305};
CautionIt is uncertain whether Met-1 or Met-23 is the initiator. {ECO:0000305}.
DomainThe Elongin BC complex binding domain is also known as BC- box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
FunctionProbable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.
PathwayProtein modification; protein ubiquitination.
Sequence CautionSequence=AAQ15266.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ15266.1; Type=Frameshift; Positions=56, 132; Evidence={ECO:0000305}; Sequence=CAA60013.1; Type=Frameshift; Positions=799; Evidence={ECO:0000305}; Sequence=CAD97609.1; Type=Frameshift; Positions=132, 186; Evidence={ECO:0000305};
SimilarityContains 7 LRR (leucine-rich) repeats. {ECO:0000305}.
SubunitPart of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2. {ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:15601820}.
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