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MGP004294

UniProt Annotations

Entry Information
Gene Namesorbin and SH3 domain containing 1
Protein EntrySRBS1_HUMAN
UniProt IDQ9BX66
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=12; Name=1 {ECO:0000269|PubMed:11374898}; IsoId=Q9BX66-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:11374898}; IsoId=Q9BX66-2; Sequence=VSP_050902, VSP_050910; Note=Ref.1 (AAK37564) sequence is in conflict in positions: 435:K->E, 452:AHCS->SRCG, 463:N->D. {ECO:0000305}; Name=3 {ECO:0000269|PubMed:11374898}; IsoId=Q9BX66-3; Sequence=VSP_050898, VSP_050900, VSP_050906, VSP_050912, VSP_050913; Name=4 {ECO:0000269|PubMed:11374898}; IsoId=Q9BX66-4; Sequence=VSP_050895, VSP_050896, VSP_050899, VSP_050900, VSP_050903, VSP_050907, VSP_050911; Note=Contains a phosphoserine at position 346. Contains a phosphoserine at position 603.; Name=5 {ECO:0000269|PubMed:11532984}; IsoId=Q9BX66-5; Sequence=VSP_050896, VSP_050901, VSP_050911; Note=Contains a phosphoserine at position 923.; Name=6 {ECO:0000269|PubMed:12504111}; IsoId=Q9BX66-6; Sequence=VSP_050896, VSP_050899, VSP_050905, VSP_050911; Note=Contains a phosphoserine at position 765.; Name=7 {ECO:0000305}; IsoId=Q9BX66-7; Sequence=VSP_050895, VSP_050896, VSP_050900, VSP_050903, VSP_050908, VSP_050909; Note=No experimental confirmation available. Contains a phosphoserine at position 469.; Name=8 {ECO:0000269|PubMed:11371513}; IsoId=Q9BX66-8; Sequence=VSP_050895, VSP_050899, VSP_050900, VSP_050904, VSP_050911; Note=Contains a phosphoserine at position 730.; Name=9 {ECO:0000305}; IsoId=Q9BX66-9; Sequence=VSP_050899, VSP_050900, VSP_050903, VSP_050911; Note=Contains a phosphoserine at position 387. Contains a phosphoserine at position 700.; Name=10 {ECO:0000305}; IsoId=Q9BX66-10; Sequence=VSP_050895, VSP_050900, VSP_050903, VSP_050907, VSP_050911; Note=No experimental confirmation available. Contains a phosphoserine at position 478. Contains a phosphoserine at position 735.; Name=11; IsoId=Q9BX66-11; Sequence=VSP_050900, VSP_039210; Name=12; IsoId=Q9BX66-12; Sequence=VSP_050895, VSP_050899, VSP_041193, VSP_050900, VSP_050904, VSP_041194, VSP_050911; Note=No experimental confirmation available. Derived from mouse ortholog data. Contains a phosphoserine at position 1213.;
FunctionPlays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
InteractionP00519:ABL1; NbExp=2; IntAct=EBI-433642, EBI-375543; O15265:ATXN7; NbExp=15; IntAct=EBI-433642, EBI-708350; P39052:Dnm2 (xeno); NbExp=5; IntAct=EBI-433642, EBI-349613; P42858:HTT; NbExp=4; IntAct=EBI-433642, EBI-466029; O15357:INPPL1; NbExp=5; IntAct=EBI-433642, EBI-1384248; Q13177:PAK2; NbExp=2; IntAct=EBI-433642, EBI-1045887;
PtmO-glycosylated. {ECO:0000250}.
Sequence CautionSequence=AAB93496.1; Type=Frameshift; Positions=861, 867, 885; Evidence={ECO:0000305}; Sequence=BAA92534.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 1 SoHo domain. {ECO:0000255|PROSITE- ProRule:PRU00195}.
SimilarityContains 3 SH3 domains. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationCell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. {ECO:0000250}.
SubunitInteracts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus. Interacts with INSM1 (By similarity). Interacts with the long isoform of MLLT4/afadin and with VCL. MLLT4 and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/FAK1 and flotillin. Interacts (via SH3 domain 2) with PXN. {ECO:0000250, ECO:0000269|PubMed:11371513, ECO:0000269|PubMed:11374898, ECO:0000269|PubMed:12504111, ECO:0000269|PubMed:17462669}.
Tissue SpecificityDetected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:11374898, ECO:0000269|PubMed:17462669}.
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