MGP Database

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MGP004295

UniProt Annotations

Entry Information
Gene Nameinterferon induced transmembrane protein 2
Protein EntryIFM2_HUMAN
UniProt IDQ01629
SpeciesHuman
Comments
Comment typeDescription
FunctionIFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637}.
InductionBy IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53. {ECO:0000269|PubMed:19544527}.
PtmPalmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus. {ECO:0000250}.
SimilarityBelongs to the CD225/Dispanin family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
SubunitInteracts with CD81. {ECO:0000250}.
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