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MGP004304

Record overview

MGPD IDMGP004304
Gene ID10606
SpeciesHomo sapiens (Human)
Gene Namephosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Gene Symbol PAICS
SynonymsADE2; AIRC; PAIS; ADE2H1;
Alternate namesmultifunctional protein ADE2; AIR carboxylase; SAICAR synthetase; multifunctional protein ADE2H1;
Chromosome4
Map Location4q12
EC Number6.3.2.6
SummaryThis gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PAICS

Proteins

multifunctional protein ADE2 isoform 1
Refseq ID:NP_001072993
Protein GI:119220559
UniProt ID:P22234
mRNA ID:NM_001079525
Length:432
RefSeq Status:
MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAVTSYKSNRIKTAFTRKCGETAFIAPQCEM
IPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIE
FGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGI
PCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGL
SNHLVWSKLRASILNTWISLKQADKKIRECNL
 
multifunctional protein ADE2 isoform 2
Refseq ID:NP_001072992
Protein GI:119220557
UniProt ID:P22234
mRNA ID:NM_001079524
Length:425
RefSeq Status:
MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVC
RRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTT
KEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVT
SAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWS
KLRASILNTWISLKQADKKIRECNL
 
multifunctional protein ADE2 isoform 2
Refseq ID:NP_006443
Protein GI:5453539
UniProt ID:P22234
mRNA ID:NM_006452
Length:425
RefSeq Status:
Protein sequence is identical to GI:119220557 (mRNA isoform)
 
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