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MGP004320

UniProt Annotations

Entry Information

Gene Name	insulin-like growth factor 2 mRNA binding protein 3
Protein Entry	IF2B3_HUMAN
UniProt ID	O00425
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00425-1; Sequence=Displayed; Name=2; IsoId=O00425-2; Sequence=VSP_024172;
Domain	All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules. {ECO:0000269\|PubMed:20080952, ECO:0000269\|PubMed:23640942}.
Function	RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta- actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269\|PubMed:16541107, ECO:0000269\|PubMed:23640942}.
Miscellaneous	Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.
Similarity	Belongs to the RRM IMP/VICKZ family. {ECO:0000305}.
Similarity	Contains 2 RRM (RNA recognition motif) domains. {ECO:0000255\|PROSITE-ProRule:PRU00176}.
Similarity	Contains 4 KH domains. {ECO:0000255\|PROSITE- ProRule:PRU00117}.
Subcellular Location	Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Subunit	Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU. {ECO:0000269\|PubMed:17289661, ECO:0000269\|PubMed:23640942}.
Tissue Specificity	Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines. {ECO:0000269\|PubMed:10525192, ECO:0000269\|PubMed:12161597, ECO:0000269\|PubMed:15644775, ECO:0000269\|PubMed:16049158, ECO:0000269\|PubMed:16814207, ECO:0000269\|PubMed:17192788, ECO:0000269\|PubMed:9178771, ECO:0000269\|PubMed:9891060}.