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MGP004321

UniProt Annotations

Entry Information
Gene Nameinsulin-like growth factor 2 mRNA binding protein 2
Protein EntryIF2B2_HUMAN
UniProt IDQ9Y6M1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=6; Name=1; IsoId=Q9Y6M1-2; Sequence=Displayed; Name=2; IsoId=Q9Y6M1-1; Sequence=VSP_036553; Name=3; IsoId=Q9Y6M1-3; Sequence=VSP_036550; Name=4; IsoId=Q9Y6M1-4; Sequence=VSP_036550, VSP_036552; Name=5; IsoId=Q9Y6M1-5; Sequence=VSP_036550, VSP_036553; Name=6; IsoId=Q9Y6M1-6; Sequence=VSP_043699; Note=Generated by alternative initiation at Met-69.;
DomainDomain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA- binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. {ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:23640942}.
FunctionRNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:9891060}.
InteractionQ14103-4:HNRNPD; NbExp=4; IntAct=EBI-1024419, EBI-432545;
MiscellaneousAutoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
Sequence CautionSequence=AAH21290.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the RRM IMP/VICKZ family. {ECO:0000305}.
SimilarityContains 2 RRM (RNA recognition motif) domains. {ECO:0000255|PROSITE-ProRule:PRU00176}.
SimilarityContains 4 KH domains. {ECO:0000255|PROSITE- ProRule:PRU00117}.
Subcellular LocationNucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
SubunitCan form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with HNRPD and IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU. {ECO:0000269|PubMed:12674497, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:23640942}.
Tissue SpecificityExpressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis. {ECO:0000269|PubMed:10190901, ECO:0000269|PubMed:16049158}.
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