MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004328

UniProt Annotations

Entry Information
Gene Nameguanine nucleotide binding protein (G protein), alpha 13
Protein EntryGNA13_HUMAN
UniProt IDQ14344
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14344-1; Sequence=Displayed; Name=2; IsoId=Q14344-2; Sequence=VSP_055140;
FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
InteractionQ92888:ARHGEF1; NbExp=3; IntAct=EBI-465387, EBI-465400; P32302:CXCR5; NbExp=9; IntAct=EBI-465387, EBI-2835269;
PtmPalmitoylation is critical for proper membrane localization and signaling. {ECO:0000269|PubMed:10747909}.
PtmPhosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation. {ECO:0000269|PubMed:12399457}.
SimilarityBelongs to the G-alpha family. G(12) subfamily. {ECO:0000305}.
Subcellular LocationMembrane; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages. In round spermatids, also present in the nuclei.
SubunitG proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. Interacts with HAX1. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22. {ECO:0000269|PubMed:15339924, ECO:0000269|PubMed:16202387, ECO:0000269|PubMed:18703424}.
Tissue SpecificityExpressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level). {ECO:0000269|PubMed:18703424}.
  logo