MGP Database

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MGP004329

UniProt Annotations

Entry Information
Gene Namechondroitin sulfate proteoglycan 5 (neuroglycan C)
Protein EntryCSPG5_HUMAN
UniProt IDO95196
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95196-1; Sequence=Displayed; Name=2; Synonyms=CSPG5-I; IsoId=O95196-2; Sequence=VSP_015761; Name=3; Synonyms=CSPG5-II; IsoId=O95196-3; Sequence=VSP_015760, VSP_015761;
Developmental StageExpressed in brain of 3 months, 5 and 10- year-old individuals. {ECO:0000269|PubMed:9950058}.
FunctionMay function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269|PubMed:15358134}.
InteractionQ8BH60:Gopc (xeno); NbExp=3; IntAct=EBI-296349, EBI-296357;
MiscellaneousDifferent forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity). {ECO:0000250}.
PtmN-glycosylated. {ECO:0000250}.
PtmO-glycosylated; contains chondroitin sulfate glycans. Part- time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation (By similarity). {ECO:0000250}.
PtmPhosphorylated; in intracellular and extracellular parts. {ECO:0000250}.
SimilarityContains 1 EGF-like domain. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts. {ECO:0000250}.
SubunitBinds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC. {ECO:0000250, ECO:0000269|PubMed:12885772, ECO:0000269|PubMed:15358134}.
Tissue SpecificityRestricted to brain (at protein level). {ECO:0000269|PubMed:9950058}.
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