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MGP004336

UniProt Annotations

Entry Information
Gene Namecanopy FGF signaling regulator 3
Protein EntryCNPY3_HUMAN
UniProt IDQ9BT09
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BT09-1; Sequence=Displayed; Name=2; IsoId=Q9BT09-2; Sequence=VSP_030132, VSP_030133; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
FunctionToll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAB91442.1; Type=Frameshift; Positions=109; Evidence={ECO:0000305}; Sequence=AAF28907.1; Type=Frameshift; Positions=252; Evidence={ECO:0000305};
SimilarityBelongs to the canopy family. {ECO:0000305}.
SimilarityContains 1 saposin B-type domain. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum {ECO:0000250}.
SubunitInteracts with HSP90B1; this interaction is disrupted in the presence of ATP. Interacts with TLR1, TLR2, TLR4 and TLR9 (By similarity). Strongest interaction with TLR4 (By similarity). {ECO:0000250}.
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