MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004349

UniProt Annotations

Entry Information
Gene Namecell adhesion molecule L1-like
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00533-1; Sequence=Displayed; Name=2; IsoId=O00533-2; Sequence=VSP_020082; Note=Glycosylated on Asn-231.;
DomainThe DGEA motif seems to be a recognition site for integrin.
DomainThe FIG[AQ]Y motif seems to be an ankyrin recruitment region.
FunctionExtracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}.
PtmCleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors.
PtmN-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3- GlcUABeta1,3GalBeta1,4GlcNAc) (By similarity). {ECO:0000250}.
PtmO-glycosylated. {ECO:0000250}.
Sequence CautionSequence=BAD92566.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. {ECO:0000305}.
SimilarityContains 4 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
SimilarityContains 6 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Soluble forms produced by cleavage/shedding also exist. {ECO:0000250}.
Subcellular LocationProcessed neural cell adhesion molecule L1- like protein: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
SubunitMay interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3 (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues. {ECO:0000269|PubMed:9799093}.
  logo