MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004350

UniProt Annotations

Entry Information
Gene Namenucleoporin 50kDa
Protein EntryNUP50_HUMAN
UniProt IDQ9UKX7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Npap60L; IsoId=Q9UKX7-1; Sequence=Displayed; Name=2; Synonyms=Npap60S; IsoId=Q9UKX7-2; Sequence=VSP_040633; Note=Contrarily to Npap60L, Npap60S does not displaces NLSs, but stabilizes their binding to importin-alpha.;
DomainContains FG repeats.
FunctionComponent of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. {ECO:0000269|PubMed:20016008}.
SimilarityContains 1 RanBD1 domain. {ECO:0000255|PROSITE- ProRule:PRU00164}.
Subcellular LocationNucleus, nuclear pore complex {ECO:0000269|PubMed:12802065}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase. {ECO:0000250}.
SubunitInteracts with Importin alpha-2, Importin beta, Importin beta-2, NUP153, Ran binding protein 7, CDKN1B and itself (By similarity). Does not interact with TPR. {ECO:0000250}.
Tissue SpecificityUbiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.
  logo