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MGP004351

UniProt Annotations

Entry Information
Gene NamecAMP-regulated phosphoprotein, 19kDa
Protein EntryARP19_HUMAN
UniProt IDP56211
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=ARPP-19; IsoId=P56211-1; Sequence=Displayed; Name=ARPP-16; IsoId=P56211-2; Sequence=VSP_018555; Note=Contains a N-acetylmethionine at position 1. {ECO:0000250};
FunctionProtein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269|PubMed:21164014}.
InductionExpression may be regulated by miR-451. {ECO:0000269|PubMed:20218812}.
PtmIsoform ARPP-16 contains a N-acetylmethionine at position 1. {ECO:0000250}.
PtmPhosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA. {ECO:0000250}.
SimilarityBelongs to the endosulfine family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitInteracts (when phosphorylated at Ser-62) with PPP2R2D (By similarity). Interacts with SNCA. {ECO:0000250, ECO:0000269|PubMed:17893145}.
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