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MGP004354

UniProt Annotations

Entry Information
Gene Namezinc finger protein 274
Protein EntryZN274_HUMAN
UniProt IDQ96GC6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=SP2114a; IsoId=Q96GC6-1; Sequence=Displayed; Name=2; Synonyms=ZNF274a; IsoId=Q96GC6-2; Sequence=VSP_006911; Name=3; Synonyms=ZNF274b; IsoId=Q96GC6-3; Sequence=VSP_006910; Name=4; Synonyms=SP2114b; IsoId=Q96GC6-4; Sequence=VSP_006912, VSP_006913;
FunctionProbable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. {ECO:0000269|PubMed:10777669}.
SimilarityBelongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}.
SimilarityContains 1 SCAN box domain. {ECO:0000255|PROSITE- ProRule:PRU00187}.
SimilarityContains 2 KRAB domains. {ECO:0000255|PROSITE- ProRule:PRU00119}.
SimilarityContains 5 C2H2-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00042}.
Subcellular LocationCytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000269|PubMed:10777669}.
SubunitInteracts with SETDB1 and TRIM28/KAP1. {ECO:0000269|PubMed:21170338}.
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