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MGP004367

UniProt Annotations

Entry Information
Gene Nameheat shock 105kDa/110kDa protein 1
Protein EntryHS105_HUMAN
UniProt IDQ92598
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=Alpha; IsoId=Q92598-1; Sequence=Displayed; Name=Beta; IsoId=Q92598-2; Sequence=VSP_002428; Name=3; IsoId=Q92598-3; Sequence=VSP_035428; Note=No experimental confirmation available.; Name=4; IsoId=Q92598-4; Sequence=VSP_054883; Note=No experimental confirmation available.;
FunctionPrevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250}.
InteractionQ96BE0:-; NbExp=3; IntAct=EBI-356829, EBI-9356686; Q62392:Phlda1 (xeno); NbExp=2; IntAct=EBI-356829, EBI-309727;
PtmPhosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. {ECO:0000250}.
Sequence CautionSequence=AAC18044.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA13192.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the heat shock protein 70 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:9931472}.
SubunitInteracts with HSPA8/HSC70. {ECO:0000250}.
Tissue SpecificityHighly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. {ECO:0000269|PubMed:10865058, ECO:0000269|PubMed:16232202}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HSPH1ID40891ch13q12.html";
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