MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004374

Record overview

MGPD IDMGP004374
Gene ID10841
SpeciesHomo sapiens (Human)
Gene Nameformimidoyltransferase cyclodeaminase
Gene Symbol FTCD
SynonymsLCHC1;
Alternate namesformimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase; formiminotransferase-cyclodeaminase;
Chromosome21
Map Location21q22.3
EC Number2.1.2.5
SummaryThe protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
OrthologsView orthologs and multiple alignments for FTCD

Proteins

formimidoyltransferase-cyclodeaminase
Refseq ID:NP_006648
Protein GI:11140815
UniProt ID:O95954
mRNA ID:NM_006657
Length:541
RefSeq Status:
MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVS
VDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARKFLIAFNINLLGTKEQAHRIA
LNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRI
RLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFRE
ASAKLTTLVDADAEAFTAYLEAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDLQVAAKALEMGVFGAYFNVLI
NLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQE
 
formimidoyltransferase-cyclodeaminase
Refseq ID:NP_996848
Protein GI:46255035
UniProt ID:O95954
mRNA ID:NM_206965
Length:541
RefSeq Status:
Protein sequence is identical to GI:11140815 (mRNA isoform)
 
  logo