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MGP004378

Record overview

MGPD IDMGP004378
Gene ID10856
SpeciesHomo sapiens (Human)
Gene NameRuvB-like AAA ATPase 2
Gene Symbol RUVBL2
SynonymsRVB2; TIH2; ECP51; TIP48; CGI-46; INO80J; REPTIN; TIP49B;
Alternate namesruvB-like 2; 48 kDa TATA box-binding protein-interacting protein; 48 kDa TBP-interacting protein; 51 kDa erythrocyte cytosolic protein; ECP-51; INO80 complex subunit J; RuvB (E coli homolog)-like 2; TAP54-beta; TIP60-associated protein 54-beta; erythrocyte cytosolic protein, 51-KD; repressing pontin 52; reptin52 protein;
Chromosome19
Map Location19q13.3
EC Number3.6.4.12
SummaryThis gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RUVBL2

Proteins

ruvB-like 2
Refseq ID:NP_006657
Protein GI:5730023
UniProt ID:Q9Y230
mRNA ID:NM_006666
Length:463
RefSeq Status:
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPF
TAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATG
KISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLR
YAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
 
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