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MGP004395

UniProt Annotations

Entry Information
Gene Namedehydrogenase/reductase (SDR family) member 4
Protein EntryDHRS4_HUMAN
UniProt IDQ9BTZ2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Name=1; Synonyms=SDR-SRL3; IsoId=Q9BTZ2-1; Sequence=Displayed; Name=2; Synonyms=SDR-SRL1; IsoId=Q9BTZ2-2; Sequence=VSP_008586; Name=3; Synonyms=SDR-SRL2; IsoId=Q9BTZ2-3; Sequence=VSP_008585; Name=4; Synonyms=NRDRB1; IsoId=Q9BTZ2-4; Sequence=VSP_031436; Name=5; Synonyms=NRDRB2; IsoId=Q9BTZ2-5; Sequence=VSP_031436, VSP_031438; Note=Contains a phosphoserine at position 140.; Name=6; Synonyms=DHRS4L2, NRDRA1; IsoId=Q9BTZ2-6; Sequence=VSP_031435; Name=7; Synonyms=NRDRA2; IsoId=Q9BTZ2-7; Sequence=VSP_031437, VSP_031439; Note=Mainly localized in the nucleus.; Name=8; Synonyms=NRDRB1; IsoId=Q9BTZ2-8; Sequence=VSP_044947, VSP_031436; Note=Enhanced dicarbonyl reductase activity. high expression in liver.;
Catalytic ActivityR-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
FunctionReduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). {ECO:0000250}.
MiscellaneousInhibited by kaempferol, quercetin, genistein and myristic acid. {ECO:0000250}.
Sequence CautionSequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationIsoform 7: Nucleus {ECO:0000269|PubMed:22227495}.
Subcellular LocationPeroxisome {ECO:0000269|PubMed:10333503}. Note=Isoform 1 is peroxisomal, while isoform 4 is not.
SubunitHomotetramer. {ECO:0000250}.
Tissue SpecificityIsoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
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