MGP Database

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MGP004397

UniProt Annotations

Entry Information
Gene Namemannosidase, alpha, class 1A, member 2
Protein EntryMA1A2_HUMAN
UniProt IDO60476
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityHydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108;
Enzyme RegulationInhibited by both 1-deoxymannojirimycin and kifunensine.
FunctionInvolved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyl hydrolase 47 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane; Single-pass type II membrane protein.
Tissue SpecificityHighest levels of expression in placenta and testis.
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