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MGP004403

Record overview

MGPD IDMGP004403
Gene ID10921
SpeciesHomo sapiens (Human)
Gene NameRNA binding protein S1, serine-rich domain
Gene Symbol RNPS1
SynonymsE5.1;
Alternate namesRNA-binding protein with serine-rich domain 1; RNA-binding protein S1, serine-rich domain; SR protein; SR-related protein LDC2;
Chromosome16
Map Location16p13.3
SummaryThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
OrthologsView orthologs and multiple alignments for RNPS1

Proteins

RNA-binding protein with serine-rich domain 1 isoform a
Refseq ID:NP_542161
Protein GI:18379334
UniProt ID:Q15287
mRNA ID:NM_080594
Length:305
RefSeq Status:
MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSS
SASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPH
LSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHRSRSS
SNSSR
 
RNA-binding protein with serine-rich domain 1 isoform a
Refseq ID:NP_006702
Protein GI:6857826
UniProt ID:Q15287
mRNA ID:NM_006711
Length:305
RefSeq Status:
Protein sequence is identical to GI:18379334 (mRNA isoform)
 
RNA-binding protein with serine-rich domain 1 isoform a
Refseq ID:NP_001273554
Protein GI:557636736
UniProt ID:Q15287
mRNA ID:NM_001286625
Length:305
RefSeq Status:
Protein sequence is identical to GI:18379334 (mRNA isoform)
 
RNA-binding protein with serine-rich domain 1 isoform b
Refseq ID:NP_001273555
Protein GI:557636738
UniProt ID:Q15287
mRNA ID:NM_001286626
Length:282
RefSeq Status:
MAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGS
PSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHM
DGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHRSRSSSNSSR
 
RNA-binding protein with serine-rich domain 1 isoform c
Refseq ID:NP_001273556
Protein GI:557636741
UniProt ID:Q15287
mRNA ID:NM_001286627
Length:257
RefSeq Status:
MAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGS
PSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHM
DGGPAPRGAGPPCAGDHGPRAAAATGAAPAPTPPDKQATEALAPVTYTPPSSVLSLF
 
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