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MGP004405

UniProt Annotations

Entry Information
Gene NameralA binding protein 1
Protein EntryRBP1_HUMAN
UniProt IDQ15311
SpeciesHuman
Comments
Comment typeDescription
FunctionCan activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. {ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:7673236}.
InteractionP78556:CCL20; NbExp=2; IntAct=EBI-749285, EBI-3913209; Q86VP1:TAX1BP1; NbExp=3; IntAct=EBI-749285, EBI-529518;
SimilarityContains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
Subcellular LocationMembrane {ECO:0000269|PubMed:11437348}; Peripheral membrane protein {ECO:0000269|PubMed:11437348}.
SubunitInteracts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis. {ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:20696399, ECO:0000269|PubMed:7673236, ECO:0000269|PubMed:9422736}.
Tissue SpecificityExpressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. {ECO:0000269|PubMed:11437348}.
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