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MGP004420

UniProt Annotations

Entry Information
Gene Namefermitin family member 2
Protein EntryFERM2_HUMAN
UniProt IDQ96AC1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96AC1-1; Sequence=Displayed; Name=2; IsoId=Q96AC1-2; Sequence=VSP_008783, VSP_008784, VSP_008785; Note=May be due to an exon inclusion and an intron retention.; Name=3; IsoId=Q96AC1-3; Sequence=VSP_008783;
DomainThe FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
DomainThe N-terminal region displays a ubiquitin-type fold and mediates interaction with membranes containing negatively charged phosphatidylinositol phosphate via a surface enriched in positively charged residues. {ECO:0000269|PubMed:22078565}.
DomainThe PH domain binds phospholipids. Binds preferentially phosphatidylinositol-3,4,5-trisphosphate, and has lower affinity for phosphatidylinositol-4,5-bisphosphate (PubMed:22030399). {ECO:0000269|PubMed:22030399}.
FunctionScaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.
InductionBy serum in lung fetal fibroblast cultured cells. {ECO:0000269|PubMed:8175911}.
InteractionP35222:CTNNB1; NbExp=13; IntAct=EBI-4399465, EBI-491549; P15884:TCF4; NbExp=6; IntAct=EBI-4399465, EBI-533224;
Sequence CautionSequence=CAA80852.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the kindlin family. {ECO:0000305}.
SimilarityContains 1 FERM domain. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
SubunitInteracts with ILK (By similarity). Interacts with FBLIM1. Interacts with ITGB1 and ITGB3. Interacts with active, unphosphorylated CTNNB1. Identified in a complex with CTNNB1 and TCF7L2/TCF4. Interacts with ITGB1; the interaction is inhibited in presence of ITGB1BP1. {ECO:0000250, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22699938}.
Tissue SpecificityUbiquitous. Found in numerous tumor tissues.
Web ResourceName=Wikipedia; Note=FERMT2 entry; URL="http://en.wikipedia.org/wiki/FERMT2";
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