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MGP004428

UniProt Annotations

Entry Information
Gene Namesolute carrier family 27 (fatty acid transporter), member 2
Protein EntryS27A2_HUMAN
UniProt IDO14975
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14975-1; Sequence=Displayed; Name=2; IsoId=O14975-2; Sequence=VSP_042726; Note=No experimental confirmation available.;
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed:11980911}.
Catalytic ActivityATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed:11980911}.
FunctionAcyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity). {ECO:0000250}.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes.
Tissue SpecificityExpressed in liver, kidney, placenta and pancreas. {ECO:0000269|PubMed:10198260}.
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