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MGP004429

UniProt Annotations

Entry Information

Gene Name	kinesin family member 2C
Protein Entry	KIF2C_HUMAN
UniProt ID	Q99661
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99661-1; Sequence=Displayed; Name=2; Synonyms=tsMCAK; IsoId=Q99661-2; Sequence=VSP_002866;
Developmental Stage	Isoform 2 is expressed in fetal testis. {ECO:0000269\|PubMed:12383881}.
Domain	The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends. {ECO:0000269\|PubMed:19632184}.
Function	In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. {ECO:0000269\|PubMed:19060894, ECO:0000269\|PubMed:21820309}.
Interaction	Q15691:MAPRE1; NbExp=5; IntAct=EBI-1642317, EBI-1004115; Q5JR59:MTUS2; NbExp=4; IntAct=EBI-1642317, EBI-742948;
Ptm	Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity. {ECO:0000269\|PubMed:14960279, ECO:0000269\|PubMed:18669648, ECO:0000269\|PubMed:20068231}.
Ptm	Ubiquitinated. {ECO:0000269\|PubMed:20596523}.
Similarity	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00283}.
Similarity	Contains 1 kinesin motor domain. {ECO:0000255\|PROSITE- ProRule:PRU00283}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. {ECO:0000250}.
Subunit	Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding. {ECO:0000269\|PubMed:11092768, ECO:0000269\|PubMed:19543227, ECO:0000269\|PubMed:19632184, ECO:0000269\|PubMed:21820309, ECO:0000269\|Ref.23}.
Tissue Specificity	Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. {ECO:0000269\|PubMed:12383881, ECO:0000269\|PubMed:9434124}.