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MGP004431

Record overview

MGPD IDMGP004431
Gene ID11010
SpeciesHomo sapiens (Human)
Gene NameGLI pathogenesis-related 1
Gene Symbol GLIPR1
SynonymsGLIPR; RTVP1; CRISP7;
Alternate namesglioma pathogenesis-related protein 1; GLI pathogenesis-related 1 (glioma); gliPR 1; protein RTVP-1; related to testis-specific, vespid, and pathogenesis proteins 1; testes-specific vespid and pathogenesis protein 1;
Chromosome12
Map Location12q21.2
SummaryThis gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GLIPR1

Proteins

glioma pathogenesis-related protein 1 precursor
Refseq ID:NP_006842
Protein GI:110825980
UniProt ID:P48060
mRNA ID:NM_006851
Length:266
RefSeq Status:
MRVTLATIAWMVSFVSNYSHTANILPDIENEDFIKDCVRIHNKFRSEVKPTASDMLYMTWDPALAQIAKAWASNCQFSHNTRLKPPHKLHPNFTSLGENI
WTGSVPIFSVSSAITNWYDEIQDYDFKTRICKKVCGHYTQVVWADSYKVGCAVQFCPKVSGFDALSNGAHFICNYGPGGNYPTWPYKRGATCSACPNNDK
CLDNLCVNRQRDQVKRYYSVVYPGWPIYPRNRYTSLFLIVNSVILILSVIITILVQHKYPNLVLLD
 
sig_peptide: 1..21
calculated_mol_wt: 2415
peptide sequence: 
MRVTLATIAWMVSFVSNYSHT

mat_peptide: 22..266
product: glioma pathogenesis-related protein 1
calculated_mol_wt: 27969
peptide sequence: 
ANILPDIENEDFIKDCVRIHNKFRSEVKPTASDMLYMTWDPALAQIAKAWASNCQFSHNTRLKPPHKLHPNFTSLGENIWTGSVPIFSVSSAITNWYDEI
QDYDFKTRICKKVCGHYTQVVWADSYKVGCAVQFCPKVSGFDALSNGAHFICNYGPGGNYPTWPYKRGATCSACPNNDKCLDNLCVNRQRDQVKRYYSVV
YPGWPIYPRNRYTSLFLIVNSVILILSVIITILVQHKYPNLVLLD
 
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