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MGP004438

UniProt Annotations

Entry Information
Gene NamePAP associated domain containing 7
Protein EntryPAPD7_HUMAN
UniProt IDQ5XG87
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=l; IsoId=Q5XG87-1; Sequence=Displayed; Name=2; Synonyms=s; IsoId=Q5XG87-2; Sequence=VSP_053732; Note=Exhibits poor nucleotidyl transferase activity.;
Catalytic ActivityATP + RNA(n) = diphosphate + RNA(n+1).
CautionWas originally thought to have DNA polymerase activity. {ECO:0000305}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
FunctionCatalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. {ECO:0000269|PubMed:23376078}.
Sequence CautionSequence=AAD45198.1; Type=Frameshift; Positions=474; Evidence={ECO:0000305};
SimilarityBelongs to the DNA polymerase type-B-like family. {ECO:0000305}.
SimilarityContains 1 PAP-associated domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm.
SubunitComponent of a nuclear TRAMP-like complex, an ATP- dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pols/";
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