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MGP004451

UniProt Annotations

Entry Information
Gene Nameheterogeneous nuclear ribonucleoprotein U-like 1
Protein EntryHNRL1_HUMAN
UniProt IDQ9BUJ2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Isoform a; IsoId=Q9BUJ2-1; Sequence=Displayed; Name=2; Synonyms=Isoform b; IsoId=Q9BUJ2-2; Sequence=VSP_017552; Name=3; IsoId=Q9BUJ2-3; Sequence=VSP_017548, VSP_017549, VSP_017551; Name=4; IsoId=Q9BUJ2-4; Sequence=VSP_017547; Name=5; IsoId=Q9BUJ2-5; Sequence=VSP_017546, VSP_017550, VSP_017551; Note=May be due to intron retention. No experimental confirmation available.;
DomainThe RGG-box domain is methylated.
FunctionActs as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand- stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.
InteractionQ9NPI1:BRD7; NbExp=5; IntAct=EBI-1018153, EBI-711221;
MiscellaneousIts methylation is enhanced in the late phase of adenoviral infection.
PtmMethylated. {ECO:0000269|PubMed:11513728, ECO:0000269|PubMed:15242333}.
SimilarityContains 1 B30.2/SPRY domain. {ECO:0000255|PROSITE- ProRule:PRU00548}.
SimilarityContains 1 SAP domain. {ECO:0000255|PROSITE- ProRule:PRU00186}.
Subcellular LocationNucleus {ECO:0000269|PubMed:11513728, ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.
SubunitInteracts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7. {ECO:0000269|PubMed:10668806, ECO:0000269|PubMed:11513728, ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:15907477, ECO:0000269|PubMed:9733834}.
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